• Association of BMI with overall and cause-specific mortality: a population-based cohort study of 3·6 million adults in the UK 

      Bhaskaran, Krishnan; dos-Santos-Silva, Isabel; Leon, David A.; Douglas, Ian J.; Smeeth, Liam (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-10-30)
      <i>Background</i>: BMI is known to be strongly associated with all-cause mortality, but few studies have been large enough to reliably examine associations between BMI and a comprehensive range of cause-specific mortality outcomes.<p> <p><i>Methods</i>: In this population-based cohort study, we used UK primary care data from the Clinical Practice Research Datalink (CPRD) linked to national ...
    • Comparing prevalence of chronic kidney disease and its risk factors between population-based surveys in Russia and Norway 

      Cook, Sarah; Solbu, Marit Dahl; Eggen, Anne Elise; Iakunchykova, Olena; Averina, Maria; Hopstock, Laila Arnesdatter; Kholmatova, Kamila Kahramonzhonovna; Kudryavtsev, Alexander V; Leon, David A.; Malyutina, Sofia; Ryabikov, Andrew; Williamson, Elizabeth; Nitsch, Dorothea (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-04-14)
      Background - Little data exists on the prevalence of chronic kidney disease (CKD) in the Russian population. We aimed to estimate the prevalence of CKD in a population-based study in Russia, compare with a similar study in Norway, and investigate whether differences in risk factors explained between-study differences in CKD.<p> <p>Methods - We compared age- and sex-standardised prevalence of ...
    • Deep learning-derived cardiovascular age shares a genetic basis with other cardiac phenotypes 

      Libiseller-Egger, Julian; Phelan, Jody E.; Attia, Zachi I.; Benavente, Ernest Diez; Campino, Susana; Friedman, Paul A.; Lopez-Jimenez, Francisco; Leon, David A.; Clark, Taane G. (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-12-31)
      Artifcial intelligence (AI)-based approaches can now use electrocardiograms (ECGs) to provide expertlevel performance in detecting heart abnormalities and diagnosing disease. Additionally, patient age predicted from ECGs by AI models has shown great potential as a biomarker for cardiovascular age, where recent work has found its deviation from chronological age (“delta age”) to be associated ...
    • Evidence of large systematic differences between countries in assigning ischaemic heart disease deaths to myocardial infarction: the contrasting examples of Russia and Norway 

      Timonin, Sergey; Shkolnikov, Vladimir M.; Andreev, Evgeny; Magnus, Per Minor; Leon, David A. (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-09-11)
      <p><i>Background:</i> There is considerable variation in mortality rates from myocardial infarction (MI) across high-income countries, some of which may be artefactual. Methods: Time trends in mortality rates from ischaemic heart disease (IHD) and MI were analysed for a set of high-income countries from the end of the 1970s. Using individuallevel mortality data from Russia (2005–2017) and Norway ...
    • Excess mortality in Russia and its regions compared to high income countries: An analysis of monthly series of 2020 

      Timonin, Sergey; Klimkin, Ilya; Shkolnikov, Vladimir M.; Andreev, Evgeny; McKee, Martin; Leon, David A. (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-12-21)
      Background: Russia has been portrayed in media as having one of the highest death tolls due to the COVID-19 pandemic in the world. However, the precise scale of excess mortality is still unclear. We provide the first estimates of excess mortality in Russia as a whole and its regions in 2020, placing this in an international context. Methods: We used monthly death rates for Russia and 83 regions ...
    • External validation of a deep learning electrocardiogram algorithm to detect ventricular dysfunction 

      Attia, Itzhak Zachi; Tseng, Andrew S.; Benavente, Ernest Diez; Medina-Inojosa, Jose R.; Clark, Taane; Malyutina, Sofia; Kapa, Suraj; Schirmer, Henrik; Kudryavtsev, Alexander V; Noseworthy, Peter A.; Carter, Rickey E.; Ryabikov, Andrey; Perel, Pablo; Friedman, Paul A.; Leon, David A.; Lopez-Jimenez, Francisco (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-01-02)
      Objective - To validate a novel artificial-intelligence electrocardiogram algorithm (AI-ECG) to detect left ventricular systolic dysfunction (LVSD) in an external population.<p> <p>Background - LVSD, even when asymptomatic, confers increased morbidity and mortality. We recently derived AI-ECG to detect LVSD using ECGs based on a large sample of patients treated at the Mayo Clinic.<p> <p>Methods ...
    • Factors associated with excess all-cause mortality in the first wave of the COVID-19 pandemic in the UK: A time series analysis using the Clinical Practice Research Datalink 

      Strongman, Helen; Carreira, Helena; De Stavola, Bianca L.; Bhaskaran, Krishnan; Leon, David A. (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-01-06)
      Background: Excess mortality captures the total effect of the Coronavirus Disease 2019 (COVID-19) pandemic on mortality and is not affected by misspecification of cause of death. We aimed to describe how health and demographic factors were associated with excess mortality during, compared to before, the pandemic. <p> <p>Methods and findings: We analysed a time series dataset including 9,635,613 ...
    • Global myocardial longitudinal strain in a general population—associations with blood pressure and subclinical heart failure: The Tromsø Study 

      Stylidis, Michael; Leon, David A.; Røsner, Assami; Schirmer, Henrik (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-12-18)
      The early detection of subclinical myocardial dysfunction can contribute to the treatment and prevention of heart failure (HF). The aim of the study was to (i) describe myocardial global longitudinal strain (GLS) patterns in a large general population sample from Norway and their relation to established cardiovascular disease (CVD) risk factors; (ii) to determine its normal thresholds in healthy ...
    • Heavy alcohol drinking and subclinical echocardiographic abnormalities of structure and function 

      Iakunchykova, Olena; Schirmer, Henrik; Leong, Darryl; Malyutina, Sofia; Ryabikov, Andrey; Averina, Maria; Kudryavtsev, Alexander V; Kornev, Mikhail; Voronina, Ekaterina; Paramonov, Andrey; Wilsgaard, Tom; Leon, David A. (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-06-02)
      Objective - The aim of the study is to assess changes in heart structure and function associated with heavy alcohol use by comparing echocardiographic indices in a population-based sample to those in patients admitted to an inpatient facility with severe alcohol problems.<p> <p>Methods and results - We used data from the Know Your Heart study (2015–2017) which is a cross-sectional study that ...
    • Left atrial diameter, left ventricle filling indices, and association with all-cause mortality: Results from the population-based Tromsø Study. 

      Stylidis, Michael; Sharashova, Ekaterina; Wilsgaard, Tom; Leon, David A.; Heggelund, Geir; Røsner, Assami; Njølstad, Inger; Løchen, Maja-Lisa; Schirmer, Henrik (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-01-28)
      <p><i>Aims</i>: To examine the associations between diastolic dysfunction indices and long‐term risk of all‐cause mortality in adults over 23‐year follow‐up.</p> <p><i>Methods and results</i>: Participants (n = 2734) of the population‐based Tromsø Study of Norway had echocardiography in 1994–1995. Of these 67% were repeated in 2001 and/or 2007–2008. Mortality between 1994 and 2016 was determined ...
    • Life history trade-offs associated with exposure to low maternal capital are different in sons compared to daughters: Evidence from a prospective Brazilian birth cohort 

      Wells, Jonathan C. K.; Cole, Tim J.; Cortina-Borja, Mario; Sear, Rebecca; Leon, David A.; Marphatia, Akanksha A.; Murray, Joseph; Wehrmeister, Fernando C.; Oliveira, Paula D.; Gonçalves, Helen; Oliveira, Isabel O.; Menezes, Ana Maria B. (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-09-20)
      Background: Environmental exposures in early life explain variability in many physiological and behavioural traits in adulthood. Recently, we showed that exposure to a composite marker of low maternal capital explained the clustering of adverse behavioural and physical traits in adult daughters in a Brazilian birth cohort. These associations were strongly mediated by whether or not the daughter had ...
    • Long-term trends in blood pressure and hypertension in Russia: an analysis of data from 14 health surveys conducted in 1975–2017 

      Churilova, Elena; Shkolnikov, Vladimir M.; Shalnova, Svetlana A.; Kudryavtsev, Alexander V; Malyutina, Sofia; Nilssen, Odd-Ragnar; Laatikainen, Tiina; Leon, David A. (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-12-07)
      Background - Hypertension is recognized as an important contributor to high cardiovascular mortality in Russia. A comprehensive analysis of data from Russian studies that measured blood pressure in population-based samples has not been previously undertaken. This study aims to identify trends and patterns in mean blood pressure and the prevalence of hypertension in Russia over the most recent ...
    • Machine-learning-derived heart and brain age are independently associated with cognition 

      Iakunchykova, Olena; Schirmer, Henrik; Vangberg, Torgil Riise; Wang, Yunpeng; Benavente, Ernest D.; van Es, René; van de Leur, Rutger R.; Lindekleiv, Haakon; Attia, Zachi I.; Lopez-Jimenez, Francisco; Leon, David A.; Wilsgaard, Tom (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-05-31)
      Background and purpose - A heart age biomarker has been developed using deep neural networks applied to electrocardiograms. Whether this biomarker is associated with cognitive function was investigated.<p> <p>Methods - Using 12-lead electrocardiograms, heart age was estimated for a population-based sample (N = 7779, age 40–85 years, 45.3% men). Associations between heart delta age (HDA) and ...
    • Management of patients with acute ST-segment elevation myocardial infarction in Russian hospitals adheres to international guidelines 

      Kontsevaya, Anna; Bates, Katie; Schirmer, Henrik; Bobrova, Natalia; Leon, David A.; McKee, Martin (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-01-23)
      <i>Objective</i> - Russia has one of the highest cardiovascular mortality rates. Modernisation of the Russian health system has been accompanied by a substantial increase in uptake of percutaneous coronary intervention (PCI), which substantially reduces the risk of mortality in patients with acute ST-elevation myocardial infarction (STEMI). This paper aims to describe contemporary Hospital treatment ...
    • Nitrate and nitrite contamination in drinking water and cancer risk: A systematic review with meta-analysis 

      Picetti, Roberto; Deeney, Megan; Pastorino, Silvia; Miller, Mark R.; Shah, Anoop; Leon, David A.; Dangour, Alan D.; Green, Rosemary (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-02-22)
      Background: Pollution of water sources, largely from wide-scale agricultural fertilizer use has resulted in nitrate and nitrite contamination of drinking water. The effects on human health of raised nitrate and nitrite levels in drinking water are currently unclear.<p> <p>Objectives: We conducted a systematic review of peer-reviewed literature on the association of nitrate and nitrite in drinking ...
    • Pharmacological management of modifiable cardiovascular risk factors (blood pressure and lipids) following diagnosis of myocardial infarction, stroke and diabetes: Comparison between population-based studies in Russia and Norway 

      Cook, Sarah Anne; Hopstock, Laila Arnesdatter; Eggen, Anne Elise; Bates, Katie; Iakunchykova, Olena; Kontsevaya, Anna; McKee, Martin; Schirmer, Henrik; Voevoda, Michael; Kudryavtsev, Alexander V; Malyutina, Sofia; Leon, David A. (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-05-19)
      <i>Background</i> - Cardiovascular disease (CVD) mortality is substantially higher in Russia than in neighbouring Norway. We aimed to compare blood pressure- and lipid-lowering medication use and proportion meeting treatment targets between general population samples in the two countries in those with CVD and diabetes.<p><p> <i>Methods</i> - The study population was adults aged 40–69 years reporting ...
    • Prevalence of symptoms, ever having received a diagnosis and treatment of depression and anxiety, and associations with health service use amongst the general population in two Russian cities 

      Cook, Sarah Anne; Kudryavtsev, Alexander V; Bobrova, Natalia; Saburova, Lyudmila; Denisova, Diana; Malyutina, Sofia; Lewis, Glyn; Leon, David A. (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-11-12)
      <i>Background</i> - Little is known about the burden of common mental disorders in Russia despite high levels of suicide and alcohol-related mortality. Here we investigated levels of symptoms, self-reports of ever having received a diagnosis and treatment of anxiety and depression in two Russian cities.<p> <p><i>Methods</i> - The study population was men and women aged 35–69 years old participating ...
    • Quantifying the contribution of established risk factors to cardiovascular mortality differences between Russia and Norway 

      Trias-Llimós, Sergi; Pennells, Lisa; Tverdal, Aage; Kudryavtsev, Alexander V; Malyutina, Sofia; Hopstock, Laila Arnesdatter; Iakunchykova, Olena; Nikitin, Yuri; Magnus, Per; Kaptoge, Stephen; Di Angelantonio, Emanuele; Leon, David A. (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-11-27)
      Surprisingly few attempts have been made to quantify the simultaneous contribution of well-established risk factors to CVD mortality differences between countries. We aimed to develop and critically appraise an approach to doing so, applying it to the substantial CVD mortality gap between Russia and Norway using survey data in three cities and mortality risks from the Emerging Risk Factor Collaboration. ...
    • Risk thresholds for alcohol consumption: combined analysis of individual-participant data for 599 912 current drinkers in 83 prospective studies 

      Wood, Angela M.; Kaptoge, Stephen; Butterworth, Adam S.; Willeit, Peter; Warnakula, Samantha; Bolton, Thomas; Paige, Ellie; Paul, Dirk S.; Sweeting, Michael; Burgess, Stephen; Bell, Steven; Astle, William; Stevens, David; Koulman, Albert; Selmer, Randi; Verschuren, W.M. Monique; Sato, Shinichi; Njølstad, Inger; Woodward, Mark; Salomaa, Veikko; Nordestgaard, Børge G.; Yeap, Bu B.; Fletcher, Astrid; Melander, Olle; Kuller, Lewis H.; Balkau, Beverley; Marmot, Michael; Koenig, Wolfgang; Casiglia, Edoardo; Cooper, Cyrus; Arndt, Volker; Franco, Oscar H.; Wennberg, Patrik; Gallacher, John; de la Cámara, Agustín Gómez; Völzke, Henry; Dahm, Christina C.; Dale, Caroline E.; Bergmann, Manuela M.; Crespo, Carlos J.; van der Schouw, Yvonne T.; Kaaks, Rudolf; Simons, Leon A.; Lagiou, Pagona; Schoufour, Josje D.; Boer, Jolanda M.A.; Key, Timothy J.; Rodriguez, Beatriz; Moreno-Iribas, Conchi; Davidson, Karina W.; Taylor, James O.; Sacerdote, Carlotta; Wallace, Robert B.; Quiros, J. Ramon; Tumino, Rosario; Blazer, Dan G.; Linneberg, Allan; Daimon, Makoto; Panico, Salvatore; Howard, Barbara; Skeie, Guri; Strandberg, Timo; Weiderpass, Elisabete; Nietert, Paul J.; Psaty, Bruce M.; Kromhout, Daan; Salamanca-Fernández, Elena; Kiechl, Stefan; Krumholz, Harlan M.; Grioni, Sara; Palli, Domenico; Huerta, Jose M.; Price, Jackie; Sundström, Johan; Arriola, Larraitz; Arima, Hisatomi; Travis, Ruth C.; Panagiotakos, Demosthenes B.; Karakatsani, Anna; Trichopoulou, Antonia; Kühn, Tilman; Grobbee, Diederick E.; Barrett-Connor, Elizabeth; van Schoor, Natasja; Boeing, Heiner; Overvad, Kim; Kauhanen, Jussi; Wareham, Nick; Langenberg, Claudia; Forouhi, Nita; Wennberg, Maria; Despres, Jean-Pierre; Cushman, Mary; Cooper, Jackie A.; Rodriguez, Carlos J.; Sakurai, Masaru; Shaw, Jonathan E.; Knuiman, Matthew; Voortman, Trudy; Meisinger, Christa; Tjønneland, Anne; Brenner, Hermann; Palmieri, Luigi; Dallongeville, Jean; Brunner, Eric J.; Assmann, Gerd; Trevisan, Maurizio; Gillum, Richard F.; Ford, Ian; Sattar, Naveed; Lazo, Mariana; Thompson, Simon G.; Ferrari, Pietro; Leon, David A.; Smith, George Davey; Peto, Richard; Jackson, Rod; Banks, Emily; Di Angelantonio, Emanuele; Danesh, John (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-04-12)
      <p><i>Background - </i>Low-risk limits recommended for alcohol consumption vary substantially across different national guidelines. To define thresholds associated with lowest risk for all-cause mortality and cardiovascular disease, we studied individual-participant data from 599 912 current drinkers without previous cardiovascular disease. <p><i>Methods - </i>We did a combined analysis of ...
    • Self-reported health as a predictor of mortality: A cohort study of its relation to other health measurements and observation time 

      Lorem, Geir; Cook, Sarah Anne; Leon, David A.; Emaus, Nina; Schirmer, Henrik (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-03-17)
      Self-reported health (SRH) is widely used as an epidemiological instrument given the changes in public health since its introduction in the 1980s. We examined the association between SRH and mortality and how this is affected by time and health measurements in a prospective cohort study using repeated measurements and physical examinations of 11652 men and 12684 women in Tromsø, Norway. We used Cox ...